Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex

Development of targeted protein degradation
therapeutics

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs

Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells